COX/5-LO-IN-1  (Synonyms: Atreleuton analog)

COX/5-LO-IN-1 (Atreleuton analog) is an inhibitor of cylooxygenase and 5-lipoxygenase (5-LO), used for the research of inflammatory and allergic disease states.

COX/5-LO-IN-1 reduces the biosynthesis of leukotrienes B4, C4, D4, and E4 and cyclooxygenase products such as prostaglandins and thromboxane and are useful in the treatment of inflammatory and allergic disease states^[1]. COX/5-LO-IN-1 shows inhibitory activities against 5-lipoxygenase, with IC₅₀ of 0.2 μM in human whole blood^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

318.37

C₁₆H₁₅FN₂O₂S

154355-75-6

O=C(N)N(C(C)C#CC1=CC=C(CC2=CC=C(F)C=C2)S1)O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Lipoxygenase and cyclooxygenase inhibiting compounds. US 5516789 A

  [2]. Brooks CD, et al. (R)-(+)-N-[3-[5-[(4-fluorophenyl)methyl]-2-thienyl]-1-methyl- 2-propynyl]-N-hydroxyurea (ABT-761), a second-generation 5-lipoxygenase inhibitor. J Med Chem. 1995 Nov 24;38(24):4768-75.  [Content Brief]